CMOS-Integrated Film Bulk Acoustic Resonators for Label-Free Biosensing

نویسندگان

  • Martin Nirschl
  • Arto Rantala
  • Kari Tukkiniemi
  • Sanna Auer
  • Ann-Charlotte Hellgren
  • Dana Pitzer
  • Matthias Schreiter
  • Inger Vikholm-Lundin
چکیده

The throughput is an important parameter for label-free biosensors. Acoustic resonators like the quartz crystal microbalance have a low throughput because the number of sensors which can be used at the same time is limited. Here we present an array of 64 CMOS-integrated film bulk acoustic resonators. We compare the performance with surface plasmon resonance and the quartz crystal microbalance and demonstrate the performance of the sensor for multiplexed detection of DNA.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Label-free Biosensing Using Cascaded Silicon-on-insulator Micro-racetrack Resonators Integrated with Pdms Microfluidic Channels

This paper demonstrates a label-free biosensing platform using Silicon-On-Insulator (SOI) micro-racetrack resonators, cascaded such that multiple measurements can be made using a single input and output waveguide and therefore a single detector. The devices are integrated with poly(dimethylsiloxane) microfluidic channels in order to characterize the devices’ sensing properties. Both bulk refrac...

متن کامل

Conformational Changes of Calmodulin on Calcium and Peptide Binding Monitored by Film Bulk Acoustic Resonators

Film bulk acoustic resonators (FBAR) are mass sensitive, label-free biosensors that allow monitoring of the interaction between biomolecules. In this paper we use the FBAR to measure the binding of calcium and the CaMKII peptide to calmodulin. Because the mass of the calcium is too small to be detected, the conformational change caused by the binding process is measured by monitoring the resona...

متن کامل

A 300μW 1.9GHz CMOS Oscillator Utilizing Micromachined Resonators

A low-power, low phase-noise 1.9GHz RF oscillator is presented. The oscillator utilizes a single thin-film bulk acoustic wave resonator and was implemented in a standard 0.18μm CMOS process. This paper addresses design issues involved in co-designing micromachined resonators with CMOS circuitry to realize ultra-low power RF transceiver components. The oscillator achieves a phase noise performan...

متن کامل

Thin film bulk acoustic wave resonators: a technology overview

This paper describes a high quality thin film piezoelectric aluminium nitride technology developed for applications in bulk acoustic wave resonators and filters. The fabrication of both SMR and FBAR resonators is described, and the main characteristics of these devices are reviewed.

متن کامل

Tunable coupled surface acoustic cavities

Related Articles Extremely low-loss acoustic phonons in a quartz bulk acoustic wave resonator at millikelvin temperature Appl. Phys. Lett. 100, 243504 (2012) Extraction of second order piezoelectric parameters in bulk acoustic wave resonators Appl. Phys. Lett. 100, 232901 (2012) Acoustic resonator based on periodically poled transducers: Concept and analysis J. Appl. Phys. 111, 064106 (2012) Vi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2010